Tacrolimus

Tacrolimus is a macrolide isolated from the culture broth of a strain of streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of t-lymphocytes in response to antigenic or mitogenic stimulation in vitro. Tacrolimus anhydrous is a calcineurin inhibitor immunosuppressant. The mechanism of action of tacrolimus anhydrous is as a calcineurin inhibitor.

Anhydrous from of tacrolimus, a macrolide isolated from streptomyces tsukubaensis. Tacrolimus binds to the fkbp-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo & prevents the activation of t-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent.

Tacrolimus Is A White Crystalline Solid Powder. It Is Soluble In Chloroform And Methanol With Melting Range Of 90°C TO 92°C.